Afuresertib HCl

Catalog No.: A13030

AKT inhibitor‎

Afuresertib HCl Chemical Structure

CAS NO. 1047645-82-8

Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Availability: In stock

Package Price Qty
5 mg
$75.00
10 mg
$100.00
25 mg
$180.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.56 mL 107.81 mL 215.62 mL
0.5 mM 4.31 mL 21.56 mL 43.12 mL
1 mM 2.16 mL 10.78 mL 21.56 mL
5 mM 0.43 mL 2.16 mL 4.31 mL

*The above data is based on the productmolecular weight 463.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13030
Actions Inhibitor
M. Wt 463.78
Formula C18H18Cl3FN4OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1047645-82-8
Synonyms GSK2110183, GSK 2110183
SMILES CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl.Cl

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