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$0.00 - Alessandra Esposito, .et al. Role of Prx1-expressing skeletal cells and Prx1-expression in fracture repair, Bone, 2020, Jul 3;139:115521 PMID: 32629173
- Nan Li, .et al. LPS-induced CXCR7 expression promotes gastric Cancer proliferation and migration via the TLR4/MD-2 pathway, Diagn Pathol, 2019, Jan 12;14(1):3 PMID: 30636642
- Ichimizu S, .et al. Cell-penetrating mechanism of intracellular targeting albumin: Contribution of macropinocytosis induction and endosomal escape, J Control Release, 2019, May 10;304:156-163 PMID: 31082432
- Kentaro Suzuki, .et al. C-terminal-modifed LY2510924: a versatile scafold for targeting C-X-C chemokine receptor type 4, Sci Rep, 2019, 9: 15284
- Thida W, .et al. The role of conventional antibodies targeting the CD4 binding site and CD4-induced epitopes in the control of HIV-1 CRF01_AE viruses, Biochem Biophys Res Commun, 2018, Nov 20. pii: S0006-291X(18)32477-X PMID: 30470571
- Henry R. Hampton, .et al. Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes, Nat Commun, 2015, 6: 7139 PMID: 25972253
Biological Activity
Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation.
Targets
| CXCL12-mediated chemotaxis (Cell-free assay) | CXCR4 (Cell-free assay) | |||
| 5.7 nM | 44 nM |
| In vitro (25°C) | DMSO | <1 mg/mL (<1 mM) | |
| Water | 3 mg/mL heating (5.96 mM) | ||
| Ethanol | 100 mg/mL (198.89 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.89 mL | 99.45 mL | 198.89 mL |
| 0.5 mM | 3.98 mL | 19.89 mL | 39.78 mL |
| 1 mM | 1.99 mL | 9.94 mL | 19.89 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.98 mL |
*The above data is based on the productmolecular weight 502.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13074 |
|---|---|
| Actions | Antagonist |
| M. Wt | 502.78 |
| Formula | C28H54N8 |
| Solubility | DMSO <1 mg/mL (<1 mM) ; Water 6 mg/mL (11 mM) ; Ethanol 100 mg/mL (198 mM) |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 110078-46-1 |
| SMILES | C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3 |
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