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Biological Activity
AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.72 mL | 108.6 mL | 217.19 mL |
| 0.5 mM | 4.34 mL | 21.72 mL | 43.44 mL |
| 1 mM | 2.17 mL | 10.86 mL | 21.72 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.34 mL |
*The above data is based on the productmolecular weight 460.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21793 |
|---|---|
| Actions | Agonist |
| CAS No. | 865231-45-4 |
| Formula | C26H20F3NaO3 |
| M. Wt | 460.42 |
| Purity | >98% |
| Synonyms | AMG837, AMG-837 |
| SMILES | [O-]C(C[[email protected]](C#CC)C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2)=O.[Na+] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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