Fig. 1 · Structure
Documents & Downloads
Amino-PEG3-C2-Azido
PROTAC Linker
Amino-PEG3-C2-Azido is a PEG-based linker designed for use in PROTAC applications, facilitating the synthesis of targeted protein degraders, such as the PARP1 degrader iRucaparib-TP3. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-bearing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds, making it a versatile tool for chemical biology and drug discovery research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 134179-38-7 |
| Applications | PROTAC Linker |
| Formula | C8H18N4O3 |
| Molecular Weight | 218.25 |
| SMILES | [N-]=[N+]=NCCOCCOCCOCCN |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.