AMPK Activator 18 is a potent allosteric activator of AMPK complexes, particularly those containing the β2 isoform. It effectively activates α2-containing AMPK α2β2γ1 and α2β2γ3 complexes, exhibiting EC50 values of 17.2 nM and 82.1 nM, respectively. This compound stimulates β2-AMPK in cellular contexts and enhances glucose uptake in isolated skeletal muscle. Additionally, AMPK Activator 18 promotes phosphorylation of acetyl-coenzyme A carboxylase (ACC) and AMPK at the α-T172 site, making it a valuable tool for research in type 2 diabetes.
AMPK Activator 18 is a potent allosteric activator of AMPK complexes, particularly those containing the β2 isoform. It effectively activates α2-containing AMPK α2β2γ1 and α2β2γ3 complexes, exhibiting EC50 values of 17.2 nM and 82.1 nM, respectively. This compound stimulates β2-AMPK in cellular contexts and enhances glucose uptake in isolated skeletal muscle. Additionally, AMPK Activator 18 promotes phosphorylation of acetyl-coenzyme A carboxylase (ACC) and AMPK at the α-T172 site, making it a valuable tool for research in type 2 diabetes.
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