Anti-CD20 Antibody (mAb 1.5.3) is a fully human IgG1 antibody targeting the CD20 antigen on B cells. This antibody exhibits significant pro-apoptotic activity in vitro and mediates both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC). In various tumor xenograft models, mAb 1.5.3 demonstrates enhanced anti-tumor efficacy. Additionally, it achieves superior B-cell depletion in lymphoid tissues and bone marrow in primate pharmacodynamic studies, making it a valuable tool for research into B-cell malignancies.
Anti-CD20 Antibody (mAb 1.5.3) is a fully human IgG1 antibody targeting the CD20 antigen on B cells. This antibody exhibits significant pro-apoptotic activity in vitro and mediates both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC). In various tumor xenograft models, mAb 1.5.3 demonstrates enhanced anti-tumor efficacy. Additionally, it achieves superior B-cell depletion in lymphoid tissues and bone marrow in primate pharmacodynamic studies, making it a valuable tool for research into B-cell malignancies.
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