Antiproliferative agent-23 is a microtubule-destabilizing agent that disrupts the tubulin-microtubule system. It induces apoptosis through a mitochondrion-dependent mechanism by downregulating Bcl-2, while upregulating Bax and Cyt c proteins, thereby activating the caspase cascade. Additionally, antiproliferative agent-23 triggers reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells via the PERK/ATF4/CHOP signaling pathway, demonstrating significant anti-tumor activity. This compound is suitable for research applications aimed at understanding cancer biology and therapeutic interventions.
Antiproliferative agent-23 is a microtubule-destabilizing agent that disrupts the tubulin-microtubule system. It induces apoptosis through a mitochondrion-dependent mechanism by downregulating Bcl-2, while upregulating Bax and Cyt c proteins, thereby activating the caspase cascade. Additionally, antiproliferative agent-23 triggers reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells via the PERK/ATF4/CHOP signaling pathway, demonstrating significant anti-tumor activity. This compound is suitable for research applications aimed at understanding cancer biology and therapeutic interventions.
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