Antitumor agent-200 is a microtubule synthesis inhibitor that targets the colchicine site on tubulin, leading to G2/M cell cycle arrest and the generation of reactive oxygen species (ROS). This compound demonstrates significant inhibitory activity against MCF7/ADR and KBV200 cell lines exhibiting P-glycoprotein overexpression, with drug resistance indices of 0.83 and 0.58, respectively. In vivo studies using the MCF-7 xenograft model have shown that Antitumor agent-200 at a dosage of 25 mg/kg via intraperitoneal injection results in a tumor growth inhibition rate of 57.2%. This reagent is valuable for research in the oncology field, particularly in studies related to drug resistance and cancer treatment efficacy.
Antitumor agent-200 is a microtubule synthesis inhibitor that targets the colchicine site on tubulin, leading to G2/M cell cycle arrest and the generation of reactive oxygen species (ROS). This compound demonstrates significant inhibitory activity against MCF7/ADR and KBV200 cell lines exhibiting P-glycoprotein overexpression, with drug resistance indices of 0.83 and 0.58, respectively. In vivo studies using the MCF-7 xenograft model have shown that Antitumor agent-200 at a dosage of 25 mg/kg via intraperitoneal injection results in a tumor growth inhibition rate of 57.2%. This reagent is valuable for research in the oncology field, particularly in studies related to drug resistance and cancer treatment efficacy.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
