APN-C3-PEG4-azide is a PEG-based PROTAC linker featuring an azide functional group, designed for the synthesis of PROTACs. It facilitates the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This versatile linker is essential for drug development studies involving targeted protein degradation and can enhance the efficiency of modular PROTAC assembly.
APN-C3-PEG4-azide is a PEG-based PROTAC linker featuring an azide functional group, designed for the synthesis of PROTACs. It facilitates the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This versatile linker is essential for drug development studies involving targeted protein degradation and can enhance the efficiency of modular PROTAC assembly.
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