AS601245 TFA is a selective, ATP-competitive inhibitor of c-Jun NH2-terminal protein kinases (JNK), demonstrating IC50 values of 150 nM for hJNK1, 220 nM for hJNK2, and 70 nM for hJNK3. This compound exhibits significant selectivity, being 10- to 20-fold more selective for JNK over kinases such as c-src, CDK2, and c-Raf, and shows more than 50- to 100-fold selectivity against various Ser/Thr and Tyr-protein kinases. AS601245 TFA is suitable for applications involving neuroprotection and the study of cellular stress response pathways in research settings.
AS601245 TFA is a selective, ATP-competitive inhibitor of c-Jun NH2-terminal protein kinases (JNK), demonstrating IC50 values of 150 nM for hJNK1, 220 nM for hJNK2, and 70 nM for hJNK3. This compound exhibits significant selectivity, being 10- to 20-fold more selective for JNK over kinases such as c-src, CDK2, and c-Raf, and shows more than 50- to 100-fold selectivity against various Ser/Thr and Tyr-protein kinases. AS601245 TFA is suitable for applications involving neuroprotection and the study of cellular stress response pathways in research settings.
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