Asterric Acid is an antibiotic fungal metabolite that selectively inhibits the binding of the vasoconstrictor endothelin-1 (ET-1) to the ETA receptor in A10 cells at a concentration of 0.1 μM. Additionally, derivatives of asterric acid demonstrate the ability to inhibit VEGF-induced tube formation in human umbilical vein endothelial cells at concentrations ranging from 3 to 10 μM, indicating its potential as an antiangiogenic agent for therapeutic applications.
Asterric Acid is an antibiotic fungal metabolite that selectively inhibits the binding of the vasoconstrictor endothelin-1 (ET-1) to the ETA receptor in A10 cells at a concentration of 0.1 μM. Additionally, derivatives of asterric acid demonstrate the ability to inhibit VEGF-induced tube formation in human umbilical vein endothelial cells at concentrations ranging from 3 to 10 μM, indicating its potential as an antiangiogenic agent for therapeutic applications.
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