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Catalog No.: A10095

Aurora/JAK inhibitor


AT9283 Chemical Structure

CAS NO. 896466-04-9

AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation.

Availability: In stock

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5 mg
10 mg
25 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Tomoya Takeda, .et al. AT9283 exhibits antiproliferative effect on tyrosine kinase inhibitor-sensitive and -resistant chronic myeloid leukemia cells by inhibition of Aurora A and Aurora B, Oncol Rep, 2020, August 18

Biological Activity

AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation.
Target Value
JAK3IC50: 1.1nM
JAK2IC50: 1.2nM
AuroraAIC50: ~3.0nM
AuroraBIC50: ~3.0nM
Abl1(T315I)IC50: 4nM
GSK-3βIC50: 1nM-10nM
FGFR2IC50: 1-10nM
VEGFR3/FLT4IC50: 1nM-10nM
MerIC50: 1nM-10nM
RETIC50: 1nM-10nM
RSK2IC50: 1nM-10nM
RSK3IC50: 1nM-10nM
TYK2IC50: 1nM-10nM
YESIC50: 1nM-10nM
Abl(Q252H)IC50: 10nM-30nM
DRAK1IC50: 10nM-30nM
FGFR1IC50: 10nM-30nM
FGFR1(V561M)IC50: 10nM-30nM
FGFR2(N549H)IC50: 10nM-30nM
FGFR3IC50: 10nM-30nM
VEGFR1/FLT1IC50: 10nM-30nM
FLT3IC50: 10nM-30nM
PDGFRα(D842V)IC50: 10nM-30nM
PDK-1IC50: 10nM-30nM
PKCμIC50: 10nM-30nM
RSK4IC50: 10nM-30nM
Src(T341M)IC50: 10nM-30nM
VEGFR2IC50: 10nM-30nM
In vitro (25°C) DMSO 68 mg/mL (178.28 mM)
Water Insoluble
Ethanol 34 mg/mL (89.13 mM)
In vivo 2% DMSO+30% PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.22 mL 131.1 mL 262.19 mL
0.5 mM 5.24 mL 26.22 mL 52.44 mL
1 mM 2.62 mL 13.11 mL 26.22 mL
5 mM 0.52 mL 2.62 mL 5.24 mL

*The above data is based on the productmolecular weight 381.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10095
Actions Inhibitor
CAS No. 896466-04-9
Formula C19H23N7O2
M. Wt 381.4
Purity >98%

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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