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ATB 429

Name: ATB 429
Brand: Adooq Bioscience
SKU: A73353
Availability: OutOfStock

Cat. No. A73353 CAS 915798-75-3

Endogenous Metabolite

ATB-429 is a novel H2S-releasing derivative of mesalamine, targeting the modulation of pain and inflammation associated with irritable bowel syndrome (IBS). It exhibits significant anti-nociceptive and anti-inflammatory activities by releasing hydrogen sulfide, effectively reducing hypersensitivity in colorectal distension models in both healthy and postcolitic rats. ATB-429 attenuates abdominal withdrawal responses, suppresses spinal c-Fos mRNA expression, and down-regulates colonic cyclooxygenase-2 and interleukin-1β mRNA levels—actions not seen with mesalamine alone. The compound's effects are mediated through ATP-sensitive K+ (KATP) channels, indicating its potential as a therapeutic agent for painful intestinal disorders linked to inflammation.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	915798-75-3
Applications	Endogenous Metabolite
Formula	C₁₆H₁₁NO₃S₃
Molecular Weight	361.46
SMILES	O=C(C1=CC(N)=CC=C1O)OC2=CC=C(C3=CSSC3=S)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.