ATB-429 is a novel H2S-releasing derivative of mesalamine, targeting the modulation of pain and inflammation associated with irritable bowel syndrome (IBS). It exhibits significant anti-nociceptive and anti-inflammatory activities by releasing hydrogen sulfide, effectively reducing hypersensitivity in colorectal distension models in both healthy and postcolitic rats. ATB-429 attenuates abdominal withdrawal responses, suppresses spinal c-Fos mRNA expression, and down-regulates colonic cyclooxygenase-2 and interleukin-1β mRNA levels—actions not seen with mesalamine alone. The compound's effects are mediated through ATP-sensitive K+ (KATP) channels, indicating its potential as a therapeutic agent for painful intestinal disorders linked to inflammation.
ATB-429 is a novel H2S-releasing derivative of mesalamine, targeting the modulation of pain and inflammation associated with irritable bowel syndrome (IBS). It exhibits significant anti-nociceptive and anti-inflammatory activities by releasing hydrogen sulfide, effectively reducing hypersensitivity in colorectal distension models in both healthy and postcolitic rats. ATB-429 attenuates abdominal withdrawal responses, suppresses spinal c-Fos mRNA expression, and down-regulates colonic cyclooxygenase-2 and interleukin-1β mRNA levels—actions not seen with mesalamine alone. The compound's effects are mediated through ATP-sensitive K+ (KATP) channels, indicating its potential as a therapeutic agent for painful intestinal disorders linked to inflammation.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
