Atramycin A

Catalog No.: A47659
Antitumor Antibiotic
Atramycin A is an isotetracenone-based antitumor antibiotic that exhibits potent cytotoxic activity against various cancer cell lines. Its mechanism involves DNA intercalation and the inhibition of topoisomerase II, leading to disruptions in DNA replication and cellular proliferation. Atramycin A is valuable for research applications focused on cancer biology and the development of new antitumor therapies.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAtramycin A is an isotetracenone-based antitumor antibiotic that exhibits potent cytotoxic activity against various cancer cell lines. Its mechanism involves DNA intercalation and the inhibition of topoisomerase II, leading to disruptions in DNA replication and cellular proliferation. Atramycin A is valuable for research applications focused on cancer biology and the development of new antitumor therapies.
Product Information
Catalog NumA47659
FormulaC25H24O9
Molecular Weight468.45
CAS Number137109-48-9
SMILESO=C(C1=C2C(O[C@H](O[C@@H](C)[C@H](O)[C@H]3O)[C@@H]3O)=CC=C1)C4=C(C5=O)C(C[C@H](C)C5)=CC(O)=C4C2=O
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