Avrainvillamide is a naturally occurring alkaloid that functions as an antibiotic by targeting the nuclear chaperone nucleophosmin (NPM1), which is often overexpressed in various human tumors. This compound exhibits antiproliferative properties by directly binding to NPM1 and Crm1, and disrupting their interactions with native cellular partners. Avrainvillamide demonstrates strong antibacterial activity against multi-drug resistant strains of Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with minimum inhibitory concentrations (MICs) of 12.5, 12.5, and 25 μg/ml, respectively. Its unique mechanism and efficacy make it a valuable tool in antibiotic research and cancer biology studies.
Avrainvillamide is a naturally occurring alkaloid that functions as an antibiotic by targeting the nuclear chaperone nucleophosmin (NPM1), which is often overexpressed in various human tumors. This compound exhibits antiproliferative properties by directly binding to NPM1 and Crm1, and disrupting their interactions with native cellular partners. Avrainvillamide demonstrates strong antibacterial activity against multi-drug resistant strains of Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with minimum inhibitory concentrations (MICs) of 12.5, 12.5, and 25 μg/ml, respectively. Its unique mechanism and efficacy make it a valuable tool in antibiotic research and cancer biology studies.
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