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Biological Activity
Azacitidine is a chemical analogue of the cytosine nucleoside used in DNA and RNA that is mainly used in the treatment of myelodysplastic syndrome (MDS).
Targets
| DNA methyltransferase (Cell-free assay) | ||||
| In vitro (25°C) | DMSO | Warmed: 45 mg/mL (184.28 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+30% PEG 300+ddH2O | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 40.95 mL | 204.75 mL | 409.5 mL |
| 0.5 mM | 8.19 mL | 40.95 mL | 81.9 mL |
| 1 mM | 4.1 mL | 20.48 mL | 40.95 mL |
| 5 mM | 0.82 mL | 4.1 mL | 8.19 mL |
*The above data is based on the productmolecular weight 244.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10105 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 320-67-2 |
| Formula | C8H12N4O5 |
| M. Wt | 244.2 |
| Purity | >98% |
| Synonyms | 5-azacytidine, Mylosar, Ladakamycin, Vidaza |
| SMILES | C1=NC(=NC(=O)N1[[email protected]]2[[email protected]@H]([[email protected]@H]([[email protected]](O2)CO)O)O)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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