AzddMeC is a potent, selective nucleoside analogue that functions as an inhibitor of HIV-1 reverse transcriptase, effectively blocking HIV-1 replication. The compound demonstrates strong antiviral activity, with EC50 values of 9 nM in HIV-1-infected human peripheral blood mononuclear cells and 6 nM in HIV-1-infected human macrophages. In addition to its antiviral properties, AzddMeC serves as a versatile click chemistry reagent, containing an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne- and DBCO- or BCN-containing molecules, respectively, making it a valuable tool in chemical biology research.
AzddMeC is a potent, selective nucleoside analogue that functions as an inhibitor of HIV-1 reverse transcriptase, effectively blocking HIV-1 replication. The compound demonstrates strong antiviral activity, with EC50 values of 9 nM in HIV-1-infected human peripheral blood mononuclear cells and 6 nM in HIV-1-infected human macrophages. In addition to its antiviral properties, AzddMeC serves as a versatile click chemistry reagent, containing an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne- and DBCO- or BCN-containing molecules, respectively, making it a valuable tool in chemical biology research.
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