Azide-PEG3-C1-Ala is a PEG-based linker designed for PROTAC (proteolysis-targeting chimera) synthesis. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) compounds. This versatile linker is essential for studying targeted protein degradation and enhancing the efficacy of therapeutic agents.
Azide-PEG3-C1-Ala is a PEG-based linker designed for PROTAC (proteolysis-targeting chimera) synthesis. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) compounds. This versatile linker is essential for studying targeted protein degradation and enhancing the efficacy of therapeutic agents.
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