Azido-PEG11-azide is a PEG-based PROTAC linker designed to facilitate the synthesis of protein degradation therapeutics. Featuring azide functional groups, it is a versatile click chemistry reagent capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, enabling effective modular assembly in drug development and chemical biology applications.
Azido-PEG11-azide is a PEG-based PROTAC linker designed to facilitate the synthesis of protein degradation therapeutics. Featuring azide functional groups, it is a versatile click chemistry reagent capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, enabling effective modular assembly in drug development and chemical biology applications.
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