Azido-PEG4-Thiol is a PEG-based linker designed specifically for PROTAC (Proteolysis Targeting Chimera) synthesis. Functioning through click chemistry, it features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG4-Thiol can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds bearing DBCO or BCN groups. This compound serves as a valuable tool in the development of targeted protein degradation strategies in chemical biology research.
Azido-PEG4-Thiol is a PEG-based linker designed specifically for PROTAC (Proteolysis Targeting Chimera) synthesis. Functioning through click chemistry, it features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG4-Thiol can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds bearing DBCO or BCN groups. This compound serves as a valuable tool in the development of targeted protein degradation strategies in chemical biology research.
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