Bardoxolone methyl (RTA 402)

Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
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Product Name Price Stock Qty
Bardoxolone methyl 25mg
$60.00
In stock
Bardoxolone methyl 50mg
$90.00
In stock
Bardoxolone methyl 100mg
$135.00
In stock
Bardoxolone methyl 200mg
$225.00
In stock
Bardoxolone methyl (RTA 402) 10mM * 1mL in DMSO
$60.00
In stock
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Adooq Products cited in reputable paper
Adooq's Bardoxolone methyl (RTA 402) has been cited by 4 publications
  • Nakamura S, .et al. , Invest Ophthalmol Vis Sci, 2019, 60: 1943-1952 PMID: 31050722
  • Hisamichi M, .et al. , Hypertens Res, 2018, Jan;41(1):8-17 PMID: 28978980
  • Takahiko Imai, .et al. , Neurobiol Dis, 2016, May;89:136-46 PMID: 26850917
  • Takagi T, .et al. , Free Radic Biol Med, 2014, 72:124-33 PMID: 24746614
  • Biological Activity
    Discription Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
    Targets
    Target Value
    Product Information
    Catalog Num A11323
    Formula C32H43NO4
    Molecular Weight 505.7
    CAS Number 218600-53-4
    SMILES C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC
    Synonyms NSC 713200, CDDO-methyl ester
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 21 mg/mL (41.52 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 4%DMSO+30% PEG300+5% Tween+61%ddH2O 2.3 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.77 mL 98.87 mL 197.75 mL
    0.5 mM 3.95 mL 19.77 mL 39.55 mL
    1 mM 1.98 mL 9.89 mL 19.77 mL
    5 mM 0.4 mL 1.98 mL 3.95 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

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      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

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