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- Hisamichi M,et al. Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone- and salt-induced renal injury, Hypertens Res, 2018, Jan;41(1):8-17 28978980
- Takahiko Imai,et al. Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation, Neurobiol Dis, 2016, May;89:136-46 26850917
- Takagi T,et al. Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury., Free Radic Biol Med., 2014, 72:124-33 24746614
|Storage||at -20°C 3 years Powder|
|Synonyms||NSC 713200, CDDO-methyl ester|
|SMILES code||C[[email protected]@]12CC[[email protected]]3(CCC(C[[email protected]]3[[email protected]]1C(=O)C=C4[[email protected]]2(CC[[email protected]@H]5[[email protected]@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC|
|Chemical Name||Methyl 2-cyano-3,12-dioxooleana-1,9(11)dien-28-oate|
|Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.|
|Solubility (25°C) *||In vitro||DMSO||21 mg/mL (41.52 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||1% DMSO/30% polyethylene glycol/1% Tween 80||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||19.77 mL||98.87 mL||197.75mL|
|0.5 mM||3.95 mL||19.77 mL||39.55 mL|
|1 mM||1.98 mL||9.89 mL||19.77 mL|
|5 mM||0.4 mL||1.98 mL||3.95 mL|
*The above data is based on the productmolecular weight 505.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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