Bardoxolone methyl (RTA 402)

Catalog No.: A11323

IκB/IKK inhibitor

Bardoxolone methyl (RTA 402)

Bardoxolone methyl (RTA 402) Chemical Structure

CAS NO. 218600-53-4

Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.

Availability: In stock

Package Price Qty
25 mg

Regular Price: $90.00

Special Price $72.00

50 mg

Regular Price: $160.00

Special Price $128.00

100 mg

Regular Price: $280.00

Special Price $224.00

200 mg

Regular Price: $450.00

Special Price $360.00

10mM * 1mL in DMSO
$77.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
Targets
IKK (Cell-free assay)
In vitro (25°C) DMSO 21 mg/mL (41.52 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.77 mL 98.87 mL 197.75 mL
0.5 mM 3.95 mL 19.77 mL 39.55 mL
1 mM 1.98 mL 9.89 mL 19.77 mL
5 mM 0.4 mL 1.98 mL 3.95 mL

*The above data is based on the productmolecular weight 505.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A11323
Actions Inhibitor
M. Wt 505.7
Formula C32H43NO4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 218600-53-4
Synonyms NSC 713200, CDDO-methyl ester
SMILES C[[email protected]@]12CC[[email protected]]3(CCC(C[[email protected]]3[[email protected]]1C(=O)C=C4[[email protected]]2(CC[[email protected]@H]5[[email protected]@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC

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