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- Nakamura S, .et al. Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability, Invest Ophthalmol Vis Sci, 2019, 60: 1943-1952
- Hisamichi M, .et al. Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone- and salt-induced renal injury, Hypertens Res, 2018, Jan;41(1):8-17 PMID: 28978980
- Takahiko Imai, .et al. Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under anticoagulation, Neurobiol Dis, 2016, May;89:136-46 PMID: 26850917
- Takagi T, .et al. Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury., Free Radic Biol Med., 2014, 72:124-33 PMID: 24746614
Biological Activity
Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
Targets
| IKK (Cell-free assay) | ||||
| In vitro (25°C) | DMSO | 21 mg/mL (41.52 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 4%DMSO+30% PEG300+5% Tween+61%ddH2O | 2.3 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.77 mL | 98.87 mL | 197.75 mL |
| 0.5 mM | 3.95 mL | 19.77 mL | 39.55 mL |
| 1 mM | 1.98 mL | 9.89 mL | 19.77 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.95 mL |
*The above data is based on the productmolecular weight 505.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11323 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 218600-53-4 |
| Formula | C32H43NO4 |
| M. Wt | 505.7 |
| Purity | >98% |
| Synonyms | NSC 713200, CDDO-methyl ester |
| SMILES | C[[email protected]@]12CC[[email protected]]3(CCC(C[[email protected]]3[[email protected]]1C(=O)C=C4[[email protected]]2(CC[[email protected]@H]5[[email protected]@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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