Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order

Bay 11-7821

Catalog No.: A11957

E2 ubiquitin conjugating enzyme inhibitor

Bay 11-7821

Bay 11-7821 Chemical Structure

CAS NO. 19542-67-7

Bay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation.

Availability: In stock

Package Price Qty
10 mg
25 mg
50 mg
100 mg
10mM * 1mL in DMSO
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Ali Nasrollahzadeh, .et al. Blockade of Nuclear Factor-??b (NF-??b) Pathway Using Bay 11-7082 Enhances Arsenic Trioxide-Induced Antiproliferative Activity in U87 Glioblastoma Cells, Rep Biochem Mol Biol, 2022, Jan;10(4):602-613 PMID: 35291620
  • Ali Nasrollahzadeh, .et al. Arsenic trioxide and BIBR1532 synergistically inhibit breast cancer cell proliferation through attenuation of NF-κB signaling pathway, Life Sci, 2020, Jul 6;257:118060 PMID: 32645343
  • Momeny M, .et al. Blockade of nuclear factor-κB (NF-κB) pathway inhibits growth and induces apoptosis in chemoresistant ovarian carcinoma cells, Int J Biochem Cell Biol, 2018, Jun;99:1-9 PMID: 29567488

Biological Activity

Bay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation.
E2-conjugating enzymes (Cell-free assay) IκBα?phosphorylation (Tumor cells)
N/A10 μM
In vitro (25°C) DMSO 39 mg/mL (188.17 mM)
Water Insoluble
Ethanol 10 mg/mL (48.25 mM)
In vivo 5% DMSO+corn oil 7 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 48.25 mL 241.25 mL 482.51 mL
0.5 mM 9.65 mL 48.25 mL 96.5 mL
1 mM 4.83 mL 24.13 mL 48.25 mL
5 mM 0.97 mL 4.83 mL 9.65 mL

*The above data is based on the productmolecular weight 207.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11957
Actions Inhibitor
CAS No. 19542-67-7
Formula C10H9NO2S
M. Wt 207.25
Purity >98%
Synonyms Bay-11-7821, Bay 117821, Bay117821,Bay 11-7082, Bay-11-7082, Bay11-7082

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy Bay 11-7821 | Bay 11-7821 Supplier | purchase | cost | manufacturer | order | distributor | buy 19542-67-7| 19542-67-7 Supplier | purchase 19542-67-7 | 19542-67-7 cost | 19542-67-7 manufacturer | order 19542-67-7 | 19542-67-7 distributor