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- Ali Nasrollahzadeh, .et al. Blockade of Nuclear Factor-??b (NF-??b) Pathway Using Bay 11-7082 Enhances Arsenic Trioxide-Induced Antiproliferative Activity in U87 Glioblastoma Cells, Rep Biochem Mol Biol, 2022, Jan;10(4):602-613 PMID: 35291620
- Ali Nasrollahzadeh, .et al. Arsenic trioxide and BIBR1532 synergistically inhibit breast cancer cell proliferation through attenuation of NF-κB signaling pathway, Life Sci, 2020, Jul 6;257:118060 PMID: 32645343
- Momeny M, .et al. Blockade of nuclear factor-κB (NF-κB) pathway inhibits growth and induces apoptosis in chemoresistant ovarian carcinoma cells, Int J Biochem Cell Biol, 2018, Jun;99:1-9 PMID: 29567488
Biological Activity
Bay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation.
Targets
| E2-conjugating enzymes (Cell-free assay) | IκBα?phosphorylation (Tumor cells) | |||
| N/A | 10 μM |
| In vitro (25°C) | DMSO | 39 mg/mL (188.17 mM) | |
| Water | Insoluble | ||
| Ethanol | 10 mg/mL (48.25 mM) | ||
| In vivo | 5% DMSO+corn oil | 7 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 48.25 mL | 241.25 mL | 482.51 mL |
| 0.5 mM | 9.65 mL | 48.25 mL | 96.5 mL |
| 1 mM | 4.83 mL | 24.13 mL | 48.25 mL |
| 5 mM | 0.97 mL | 4.83 mL | 9.65 mL |
*The above data is based on the productmolecular weight 207.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11957 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 19542-67-7 |
| Formula | C10H9NO2S |
| M. Wt | 207.25 |
| Purity | >98% |
| Synonyms | Bay-11-7821, Bay 117821, Bay117821,Bay 11-7082, Bay-11-7082, Bay11-7082 |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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