BAY-866 is an allosteric inhibitor of MEK1, exhibiting an IC50 of 14 nM. This compound effectively inhibits cell proliferation in A375 (BRAF) and HCT116 (K-Ras) cell lines, with respective IC50 values of 13 nM and 277 nM. Additionally, BAY-866 demonstrates anti-tumor activity in K-Ras-mutated A549 xenograft models, making it a valuable tool for research in cancer biology and targeted therapies.
BAY-866 is an allosteric inhibitor of MEK1, exhibiting an IC50 of 14 nM. This compound effectively inhibits cell proliferation in A375 (BRAF) and HCT116 (K-Ras) cell lines, with respective IC50 values of 13 nM and 277 nM. Additionally, BAY-866 demonstrates anti-tumor activity in K-Ras-mutated A549 xenograft models, making it a valuable tool for research in cancer biology and targeted therapies.
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