BDE 47 is a JNK activator that targets mitochondria to inhibit mitochondrial oxidative phosphorylation (OXPHOS). This compound decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cells. Additionally, BDE 47 triggers the generation of reactive oxygen species (ROS) and activates the JNK signaling pathway, demonstrating embryonic developmental toxicity in zebrafish models. Its unique properties make it a valuable tool for research on oxidative stress and developmental biology.
BDE 47 is a JNK activator that targets mitochondria to inhibit mitochondrial oxidative phosphorylation (OXPHOS). This compound decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cells. Additionally, BDE 47 triggers the generation of reactive oxygen species (ROS) and activates the JNK signaling pathway, demonstrating embryonic developmental toxicity in zebrafish models. Its unique properties make it a valuable tool for research on oxidative stress and developmental biology.
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