- Hosoi T, .et al. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death, Neurosci Lett, 2016, Aug 26;629:241-244 PMID: 27443785
Biological Activity
BIBR 1532 is a selective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively).
Targets
Telomerase (Cell-free assay) | ||||
100 nM |
In vitro (25°C) | DMSO | 66 mg/mL (199.17 mM) | |
Water | <1 mg/mL (<1 mM) | ||
Ethanol | 3 mg/mL (9.05 mM) | ||
In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol | 30 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 30.18 mL | 150.88 mL | 301.75 mL |
0.5 mM | 6.04 mL | 30.18 mL | 60.35 mL |
1 mM | 3.02 mL | 15.09 mL | 30.18 mL |
5 mM | 0.6 mL | 3.02 mL | 6.04 mL |
*The above data is based on the productmolecular weight 331.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10140 |
---|---|
Actions | Inhibitor |
M. Wt | 331.4 |
Formula | C21H17NO3 |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 321674-73-1 |
Synonyms | BIBR-1532, BIBR1532 |
SMILES | C/C(=C\C(=O)NC1=CC=CC=C1C(=O)O)/C2=CC3=CC=CC=C3C=C2 |
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