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$0.00 - Hosoi T, .et al. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death, Neurosci Lett, 2016, Aug 26;629:241-244 PMID: 27443785
Biological Activity
BIBR 1532 is a selective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively).
Targets
| Telomerase (Cell-free assay) | ||||
| 100 nM |
| In vitro (25°C) | DMSO | 58 mg/mL (175.03 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (9.05 mM) | ||
| In vivo | 5% DMSO+corn oil | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.18 mL | 150.88 mL | 301.75 mL |
| 0.5 mM | 6.04 mL | 30.18 mL | 60.35 mL |
| 1 mM | 3.02 mL | 15.09 mL | 30.18 mL |
| 5 mM | 0.6 mL | 3.02 mL | 6.04 mL |
*The above data is based on the productmolecular weight 331.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10140 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 321674-73-1 |
| Formula | C21H17NO3 |
| M. Wt | 331.4 |
| Purity | >98% |
| Synonyms | BIBR-1532, BIBR1532 |
| SMILES | C/C(=C\C(=O)NC1=CC=CC=C1C(=O)O)/C2=CC3=CC=CC=C3C=C2 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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