BMS 275183 is a potent orally active analogue of Paclitaxel that targets microtubule stabilization. This compound exhibits significant antitumor activity in in vivo models, demonstrating efficacy against Paclitaxel-resistant tumors, including those with tubulin mutations or overexpressing P-glycoprotein. BMS 275183 is valuable for cancer research applications, particularly in studying non-small cell lung cancer (NSCLC) and prostate carcinoma.
BMS 275183 is a potent orally active analogue of Paclitaxel that targets microtubule stabilization. This compound exhibits significant antitumor activity in in vivo models, demonstrating efficacy against Paclitaxel-resistant tumors, including those with tubulin mutations or overexpressing P-glycoprotein. BMS 275183 is valuable for cancer research applications, particularly in studying non-small cell lung cancer (NSCLC) and prostate carcinoma.
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