BRD5648 serves as a negative control for the potent GSK-3α inhibitor, BRD0705. This compound selectively targets GSK-3α with an IC50 of 66 nM, demonstrating up to an 8-fold preference over GSK-3β, which has an IC50 of 515 nM. Research applications for BRD5648 include investigations into mechanisms of action for GSK-3 inhibition, particularly in the context of acute myeloid leukemia (AML) and related hematological malignancies.
BRD5648 serves as a negative control for the potent GSK-3α inhibitor, BRD0705. This compound selectively targets GSK-3α with an IC50 of 66 nM, demonstrating up to an 8-fold preference over GSK-3β, which has an IC50 of 515 nM. Research applications for BRD5648 include investigations into mechanisms of action for GSK-3 inhibition, particularly in the context of acute myeloid leukemia (AML) and related hematological malignancies.
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