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Biological Activity
BRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively).
Targets
| HDAC6 | HDAC8 | HDAC2 | HDAC4 | |
| 36 nM | 120 nM | 9 μM | >33 μM |
| In vitro | DMSO | 49 mg/mL (172.34 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 8 mg/mL (28.13 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.17 mL | 175.87 mL | 351.74 mL |
| 0.5 mM | 7.03 mL | 35.17 mL | 70.35 mL |
| 1 mM | 3.52 mL | 17.59 mL | 35.17 mL |
| 5 mM | 0.7 mL | 3.52 mL | 7.03 mL |
*The above data is based on the productmolecular weight 284.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15489 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1440209-96-0 |
| Formula | C16H16N2O3 |
| M. Wt | 284.3 |
| Purity | >98% |
| Synonyms | BRD-73954, BRD 73954 |
| SMILES | C1=CC=C(C=C1)CCNC(=O)C2=CC(=CC=C2)C(=O)NO |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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