BS-153

Catalog No.: A79619
Anti-inflammatory Agent
BS-153 is a synthetic oxazolidinone compound that functions as an anti-inflammatory agent by inhibiting the activation of the NF-κB/PKCθ signaling pathway. It effectively reduces the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6, in LPS-stimulated RAW264.7 macrophage cells. This reagent is suitable for research applications focused on inflammation and immune response modulation.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBS-153 is a synthetic oxazolidinone compound that functions as an anti-inflammatory agent by inhibiting the activation of the NF-κB/PKCθ signaling pathway. It effectively reduces the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6, in LPS-stimulated RAW264.7 macrophage cells. This reagent is suitable for research applications focused on inflammation and immune response modulation.
Product Information
Catalog NumA79619
FormulaC27H26ClF3N6O2
Molecular Weight558.98
CAS Number1935692-54-8
SMILESFC(F)(F)C1=C(NC(C2=CC=C(N3CCC(N4CCOCC4)CC3)C(C#N)=C2)=O)C=NN1C5=CC=C(Cl)C=C5
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