Total item
Cart Subtotal
$0.00 Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
- Lisann Pelzl, .et al. Antibody-mediated procoagulant platelet formation in COVID-19 is AKT dependent, J Thromb Haemost, 2022, Feb;20(2):387-398 PMID: 34752677
- J Wei, .et al. Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling, bioRxiv, 2018, 2018
- Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
Biological Activity
BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.
Targets
| PI3Kα (Cell-free assay) | ||||
| 5 nM |
| In vitro (25°C) | DMSO | 77 mg/mL (174.41 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL (4.53 mM) | ||
| In vivo | 5%DMSO+40%PEG300+5%Tween80+50%ddH2O | 4.1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.65 mL | 113.25 mL | 226.5 mL |
| 0.5 mM | 4.53 mL | 22.65 mL | 45.3 mL |
| 1 mM | 2.27 mL | 11.33 mL | 22.65 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.53 mL |
*The above data is based on the productmolecular weight 441.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11328 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1217486-61-7 |
| Formula | C19H22F3N5O2S |
| M. Wt | 441.5 |
| Purity | >98% |
| Synonyms | BYL-719 |
| SMILES | CC1=C(SC(=N1)NC(=O)N2CCC[[email protected]]2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy BYL719 (Alpelisib) | BYL719 (Alpelisib) Supplier | purchase | cost | manufacturer | order | distributor | buy 1217486-61-7| 1217486-61-7 Supplier | purchase 1217486-61-7 | 1217486-61-7 cost | 1217486-61-7 manufacturer | order 1217486-61-7 | 1217486-61-7 distributor
Featured PI3K inhibitors
-
BAY 80-6946 (Copanlisib)
BAY 80-6946 is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. -
BEZ235 (NVP-BEZ235, Dactolisib)
BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. -
BKM120 (NVP-BKM120, Buparlisib)
BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor. -
BYL719 (Alpelisib)
BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. -
CUDC-907 (Fimepinostat)
CUDC-907 (Fimepinostat) is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses. -
CZC24832
CZC24832 is a selective inhibitor of PI 3-Kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay). -
GDC-0941 (Pictilisib)
GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) , with IC50 values (nM) of 3, 33, 3, 75, 1230 and 580 for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively. -
GSK1059615
GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM). -
GSK2636771
GSK2636771 is a potent, orally bioavailable, PI3K beta-selective inhibitor. -
LY294002
LY294002 is a PI3k inhibitor (cell IC50 about 10 μM) and a casein kinase II inhibitor. -
LY3023414
LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242). -
NU-7441 (KU-57788)
NU-7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. The IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively. -
PI-3065
PI-3065 is a small molecule and selective inhibitor of p110δ kinase with an Ki value of 1.5nM and IC50 value of 5nM -
PIK-75 hydrochloride
PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively. -
PIK-93
PIK 93 selectively inhibits the type III PI 4-kinase enzyme, and small interfering RNA-mediated down-regulation of the individual PI 4-kinase enzymes. -
TGX-221
TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β. -
XL147 analogue
XL147 is a potent, selective and orally bioavailable small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K) with potential antineoplastic activity. -
YM201636
YM201636 is a cell-permeable and selective inhibitor of PIKfyve (IC50 = 33 nM). -
ZSTK474
ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms.
Adooq Quality Guarantee
We promise all products perform as described.