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BYL719 (Alpelisib)

Catalog No.: A11328

PI3K Inhibitor

BYL719 (Alpelisib)

BYL719 (Alpelisib) Chemical Structure

CAS NO. 1217486-61-7

BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg
10 mg
25 mg
50 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Lisann Pelzl, .et al. Antibody-mediated procoagulant platelet formation in COVID-19 is AKT dependent, J Thromb Haemost, 2022, Feb;20(2):387-398 PMID: 34752677
  • J Wei, .et al. Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling, bioRxiv, 2018, 2018
  • Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844

Biological Activity

BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.
PI3Kα (Cell-free assay)
5 nM
In vitro (25°C) DMSO 77 mg/mL (174.41 mM)
Water Insoluble
Ethanol 2 mg/mL (4.53 mM)
In vivo 5%DMSO+40%PEG300+5%Tween80+50%ddH2O 4.1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.65 mL 113.25 mL 226.5 mL
0.5 mM 4.53 mL 22.65 mL 45.3 mL
1 mM 2.27 mL 11.33 mL 22.65 mL
5 mM 0.45 mL 2.27 mL 4.53 mL

*The above data is based on the productmolecular weight 441.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11328
Actions Inhibitor
CAS No. 1217486-61-7
Formula C19H22F3N5O2S
M. Wt 441.5
Purity >98%
Synonyms BYL-719
SMILES CC1=C(SC(=N1)NC(=O)N2CCC[[email protected]]2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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