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- Zhifeng Zhang, .et al. XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers, PLoS One, 2017, 12(10): e0186900 PMID: 29049411
Biological Activity
C646 is a selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM).
Targets
| p300/CBP (Cell-free assay) | ||||
| 400 nM(Ki) |
| In vitro (25°C) | DMSO | 13 mg/mL (29.18 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+40% PEG 300+5%Tween 80+ddH2O | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.45 mL | 112.25 mL | 224.51 mL |
| 0.5 mM | 4.49 mL | 22.45 mL | 44.9 mL |
| 1 mM | 2.25 mL | 11.23 mL | 22.45 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.49 mL |
*The above data is based on the productmolecular weight 445.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12815 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 328968-36-1 |
| Formula | C24H19N3O6 |
| M. Wt | 445.42 |
| Purity | >98% |
| Synonyms | C 646, C-646 |
| SMILES | CC1=C(C=C(C(=C1)C2=CC=C(O2)/C=C\3/C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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