Cabazitaxel

Catalog No.: A11831

Microtubule Associated inhibitor

Cabazitaxel

Cabazitaxel Chemical Structure

CAS NO. 183133-96-2

Cabazitaxel is a semi-synthetic derivative of a natural taxoid. Cabazitaxel in combination with prednisone is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment

Availability: In stock

Package Price Qty
50 mg
$80.00
100 mg
$170.00
250 mg
$300.00
10mM * 1mL in DMSO
$72.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Tomohiro Nabekura, .et al. Microtubule-targeting anticancer drug eribulin induces drug efflux transporter P-glycoprotein, Biochem Biophys Rep, 2020, Mar; 21: 100727 PMID: 31993509

Biological Activity

Cabazitaxel is a semi-synthetic derivative of a natural taxoid. Cabazitaxel in combination with prednisone is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment
Targets
Microtubule (Cell-free assay)
In vitro DMSO 91 mg/mL (108.85 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.96 mL 59.81 mL 119.63 mL
0.5 mM 2.39 mL 11.96 mL 23.93 mL
1 mM 1.2 mL 5.98 mL 11.96 mL
5 mM 0.24 mL 1.2 mL 2.39 mL

*The above data is based on the productmolecular weight 835.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11831
Actions Inhibitor
CAS No. 183133-96-2
Formula C45H57NO14
M. Wt 835.93
Purity >98%
Synonyms TXD-258, XRP 6258
SMILES CC1=C2[[email protected]](C(=O)[[email protected]@]3([[email protected]](C[[email protected]@H]4[[email protected]]([[email protected]]3[[email protected]@H]([[email protected]@](C2(C)C)(C[[email protected]@H]1OC(=O)[[email protected]@H]([[email protected]](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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