Cercosporamide

Catalog No.: A15362

Mnk2/JAK3 inhibitor

Cercosporamide

Cercosporamide Chemical Structure

CAS NO. 131436-22-1

Cercosporamide, an usnic amide, was originally identified in Cercosporidium henningsii as a host-selective phytotoxin and broad-spectrum antifungal agent and is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2; IC50 = 11 nM), JAK3 (IC50 = 31), and Mnk1 (IC50 = 116 nM).

Availability: Out of stock

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0.5 mg

Regular Price: $160.00

Special Price $128.00

1 mg

Regular Price: $300.00

Special Price $240.00

2.5 mg

Regular Price: $600.00

Special Price $480.00

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Biological Activity

Cercosporamide, an usnic amide, was originally identified in Cercosporidium henningsii as a host-selective phytotoxin and broad-spectrum antifungal agent and is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2; IC50 = 11 nM), JAK3 (IC50 = 31), and Mnk1 (IC50 = 116 nM).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.19 mL 150.93 mL 301.86 mL
0.5 mM 6.04 mL 30.19 mL 60.37 mL
1 mM 3.02 mL 15.09 mL 30.19 mL
5 mM 0.6 mL 3.02 mL 6.04 mL

*The above data is based on the productmolecular weight 331.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15362
Actions Inhibitor
CAS No. 131436-22-1
Formula C16H13NO7
M. Wt 331.28
Purity >98%
SMILES CC(=O)C1=C(C=C2C(C1=O)(C3=C(C=C(C(=C3O2)C(=O)N)O)O)C)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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