CHDI-00484077 is a class IIa HDAC inhibitor that demonstrates potent inhibitory activity against HDAC4 (IC50 = 0.01 μM), HDAC5 (IC50 = 0.02 μM), HDAC7 (IC50 = 0.02 μM), and HDAC9 (IC50 = 0.03 μM). This compound is capable of penetrating the central nervous system, making it a valuable tool for research applications related to Huntington's disease. Its selective activity on histone deacetylases offers insights into epigenetic regulation and therapeutic strategies in neurodegenerative disorders.
CHDI-00484077 is a class IIa HDAC inhibitor that demonstrates potent inhibitory activity against HDAC4 (IC50 = 0.01 μM), HDAC5 (IC50 = 0.02 μM), HDAC7 (IC50 = 0.02 μM), and HDAC9 (IC50 = 0.03 μM). This compound is capable of penetrating the central nervous system, making it a valuable tool for research applications related to Huntington's disease. Its selective activity on histone deacetylases offers insights into epigenetic regulation and therapeutic strategies in neurodegenerative disorders.
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