CHDI-390576

Catalog No.: A18899

HDAC inhibitor

CHDI-390576

CHDI-390576 Chemical Structure

CAS NO. 1629729-98-1

CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histonedeacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,000.00
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Biological Activity

CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histonedeacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.55 mL 127.77 mL 255.54 mL
0.5 mM 5.11 mL 25.55 mL 51.11 mL
1 mM 2.56 mL 12.78 mL 25.55 mL
5 mM 0.51 mL 2.56 mL 5.11 mL

*The above data is based on the productmolecular weight 391.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18899
Actions Inhibitor
M. Wt 391.33
Formula C19H13F4N3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1629729-98-1
Synonyms CHDI390576, CHDI 390576
SMILES O=C(NO)C(C1=CC=CC=C1F)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2

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