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CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histonedeacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.55 mL | 127.77 mL | 255.54 mL |
| 0.5 mM | 5.11 mL | 25.55 mL | 51.11 mL |
| 1 mM | 2.56 mL | 12.78 mL | 25.55 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.11 mL |
*The above data is based on the productmolecular weight 391.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18899 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 391.33 |
| Formula | C19H13F4N3O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1629729-98-1 |
| Synonyms | CHDI390576, CHDI 390576 |
| SMILES | O=C(NO)C(C1=CC=CC=C1F)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2 |
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