Cimicifugic acid D (2-Caffeoylpiscidic acid) is a benzyltartaric acid ester that acts as a vasodilator, promoting endothelium-independent relaxation in precontracted rat aortic strips. Its primary mechanism involves the inhibition of extracellular Ca2+ influx through receptor-operated calcium channels (ROC), effectively countering norepinephrine-induced contractions. Notably, Cimicifugic acid D does not interfere with voltage-dependent calcium channels or K+-induced contractions, making it a valuable tool for studying vascular smooth muscle responses and calcium signaling pathways.
Cimicifugic acid D (2-Caffeoylpiscidic acid) is a benzyltartaric acid ester that acts as a vasodilator, promoting endothelium-independent relaxation in precontracted rat aortic strips. Its primary mechanism involves the inhibition of extracellular Ca2+ influx through receptor-operated calcium channels (ROC), effectively countering norepinephrine-induced contractions. Notably, Cimicifugic acid D does not interfere with voltage-dependent calcium channels or K+-induced contractions, making it a valuable tool for studying vascular smooth muscle responses and calcium signaling pathways.
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