Concanamycin B

Catalog No.: A46846
Antibiotic
Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar-type H+-ATPases, with an IC50 value of 5 nM. This inhibition disrupts proton gradient formation, leading to membrane potential alterations in target cells. Concanamycin B is widely used in research to study cellular ion homeostasis, lysosomal function, and autophagy processes.
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Size Price Stock Qty
1mg
$1,505.00
In stock
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionConcanamycin B is a macrolide antibiotic that selectively inhibits vacuolar-type H+-ATPases, with an IC50 value of 5 nM. This inhibition disrupts proton gradient formation, leading to membrane potential alterations in target cells. Concanamycin B is widely used in research to study cellular ion homeostasis, lysosomal function, and autophagy processes.
Product Information
Catalog NumA46846
FormulaC44H71NO14
Molecular Weight838.03
CAS Number81552-33-2
SMILESO=C1O[C@H]([C@@H](C)[C@@H](O)[C@@H]([C@@]2(O)C[C@@H](O[C@H]3C[C@H]([C@@H]([C@@H](C)O3)OC(N)=O)O)[C@H](C)[C@@H](/C=C/C)O2)C)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)\C=C1/O
SynonymsMCH 210
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