CPU-228 is a complex class III antiarrhythmic agent primarily targeting the rapid component of the delayed rectifier potassium channel (IKr) and L-type calcium channel (ICa,L). It exhibits concentration-dependent inhibition of ICa,L with an IC50 of 0.909 μM. Biological assays demonstrate that CPU-228 generates negative inotropic effects and induces a mild, non-frequency-dependent prolongation of the effective refractory period (ERP) in isolated left atrial tissues. Additionally, CPU-228 is effective in reducing the incidence of torsades de pointes in anesthetized rabbits and inhibits ischemia/reperfusion-induced arrhythmias in rats, making it a valuable tool for research on arrhythmias and cardiac electrophysiology.
CPU-228 is a complex class III antiarrhythmic agent primarily targeting the rapid component of the delayed rectifier potassium channel (IKr) and L-type calcium channel (ICa,L). It exhibits concentration-dependent inhibition of ICa,L with an IC50 of 0.909 μM. Biological assays demonstrate that CPU-228 generates negative inotropic effects and induces a mild, non-frequency-dependent prolongation of the effective refractory period (ERP) in isolated left atrial tissues. Additionally, CPU-228 is effective in reducing the incidence of torsades de pointes in anesthetized rabbits and inhibits ischemia/reperfusion-induced arrhythmias in rats, making it a valuable tool for research on arrhythmias and cardiac electrophysiology.
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