Crizotinib hydrochloride

Catalog No.: A16245

c-Met/NPM-ALK inhibitor

Crizotinib hydrochloride

Crizotinib hydrochloride Chemical Structure

CAS NO. 1415560-69-8

Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK.

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  • Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277

Biological Activity

Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.54 mL 102.71 mL 205.42 mL
0.5 mM 4.11 mL 20.54 mL 41.08 mL
1 mM 2.05 mL 10.27 mL 20.54 mL
5 mM 0.41 mL 2.05 mL 4.11 mL

*The above data is based on the productmolecular weight 486.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16245
Actions Inhibitor
CAS No. 1415560-69-8
Formula C21H23Cl3FN5O
M. Wt 486.8
Purity >98%
Synonyms PF-02341066 hydrochloride, PF 02341066 hydrochloride
SMILES C[[email protected]](OC(C=C(C(C=N1)=CN1C2CCNCC2)C=N3)=C3N)([H])C4=C(Cl)C=CC(F)=C4Cl.Cl

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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