PF-2341066 (Crizotinib)

Catalog No.: A10712
ALK/ c-Met inhibitor
PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).
Grouped product items
Product Name Price Stock Qty
PF-2341066 5mg
In stock
PF-2341066 10mg
In stock
PF-2341066 50mg
In stock
PF-2341066 100mg
In stock

Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's PF-2341066 (Crizotinib) has been cited by 6 publications
  • Reiko Watanabe, .et al. , J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
  • Yu B, .et al. , J Sep Sci, 2020, Jan 22 PMID: 31970927
  • Li Li, .et al. , Leukemia Res, 2019, 78:12-20 PMID: 30660961
  • Li T, .et al. , Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
  • Saki Omote, .et al. , Sci Rep, 2018, 8: 9237 PMID: 29915248
  • Arakawa H, .et al. , J Pharm Sci, 2017, Sep;106(9):2899-2903 PMID: 28336299
  • Biological Activity
    Discription PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).
    Target Value
    Chemical Information
    Catalog Num A10712
    Formula C21H22Cl2FN5O
    Molecular Weight 450.3
    CAS Number 877399-52-5
    SMILES C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
    Synonyms PF02341066

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro (25°C) DMSO 8 mg/mL (17.76 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5% DMSO+30% PEG 300+dd H2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.21 mL 111.04 mL 222.07 mL
    0.5 mM 4.44 mL 22.21 mL 44.41 mL
    1 mM 2.22 mL 11.1 mL 22.21 mL
    5 mM 0.44 mL 2.22 mL 4.44 mL
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