PF-2341066 (Crizotinib)

Catalog No.: A10712

ALK/ c-Met inhibitor

PF-2341066 (Crizotinib)

PF-2341066 (Crizotinib) Chemical Structure

CAS NO. 877399-52-5

PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $30.00

Special Price $24.00

10 mg

Regular Price: $50.00

Special Price $40.00

50 mg

Regular Price: $100.00

Special Price $80.00

100 mg

Regular Price: $140.00

Special Price $112.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).
Targets
c-Met (A549, MDA-MB-231, GTL-16, HT29, 786-O, Colo-205, A498 cells) ALK (Karpas299 cells)
11 nM24 nM
In vitro (25°C) DMSO 9 mg/mL (19.98 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC Na 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.21 mL 111.04 mL 222.07 mL
0.5 mM 4.44 mL 22.21 mL 44.41 mL
1 mM 2.22 mL 11.1 mL 22.21 mL
5 mM 0.44 mL 2.22 mL 4.44 mL

*The above data is based on the productmolecular weight 450.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10712
Actions Inhibitor
M. Wt 450.3
Formula C21H22Cl2FN5O
Solubility DMSO>23mg/mL Water<1mg/mL Ethanol>8mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 877399-52-5
Synonyms PF02341066
SMILES C[[email protected]](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

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