(S)-crizotinib

Catalog No.: A14291

MTH1 (NUDT1) inhibitor

(S)-crizotinib

(S)-crizotinib Chemical Structure

CAS NO. 1374356-45-2

(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.

Availability: In stock

Package Price Qty
10 mg
$150.00
25 mg
$300.00
50 mg
$500.00
10mM * 1mL in DMSO
$127.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.
Targets
MTH1 (Cell-free assay)
72 nM
In vitro DMSO 42 mg/mL heating (93.26 mM)
Water <1 mg/mL (<1 mM)
Ethanol 22 mg/mL (48.85 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.21 mL 111.03 mL 222.05 mL
0.5 mM 4.44 mL 22.21 mL 44.41 mL
1 mM 2.22 mL 11.1 mL 22.21 mL
5 mM 0.44 mL 2.22 mL 4.44 mL

*The above data is based on the productmolecular weight 450.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A14291
Actions Inhibitor
M. Wt 450.34
Formula C21H22Cl2FN5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1374356-45-2
Synonyms N/A
SMILES C[[email protected]@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

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