Catalog No.: A14291

MTH1 (NUDT1) inhibitor


(S)-crizotinib Chemical Structure

CAS NO. 1374356-45-2

(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.

Availability: In stock

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10 mg
25 mg
50 mg
10mM * 1mL in DMSO
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Biological Activity

(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.
MTH1 (Cell-free assay)
72 nM
In vitro DMSO Warmed: 42 mg/mL (93.26 mM)
Water Insoluble
Ethanol 22 mg/mL (48.85 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.21 mL 111.03 mL 222.05 mL
0.5 mM 4.44 mL 22.21 mL 44.41 mL
1 mM 2.22 mL 11.1 mL 22.21 mL
5 mM 0.44 mL 2.22 mL 4.44 mL

*The above data is based on the productmolecular weight 450.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14291
Actions Inhibitor
CAS No. 1374356-45-2
Formula C21H22Cl2FN5O
M. Wt 450.34
Purity >98%
SMILES C[[email protected]@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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