Curdione, a naturally occurring sesquiterpenoid, exhibits significant anti-platelet aggregation activity and plays a pivotal role in modulating ferroptosis in colorectal cancer through m6A methylation processes involving METTL14 and YTHDF2. This compound is effective in alleviating myocardial infarction-induced oxidative stress via the Keap1/Trx1/GPX4 signaling pathway and mitigating Doxorubicin-induced cardiotoxicity through activation of the Nrf2/HO-1 pathway. Additionally, Curdione demonstrates protective properties against sepsis-induced lung injury, pulmonary fibrosis, and focal cerebral ischemia, while also exhibiting antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Its modulation of DNMT1-mediated ERBB4 promoter methylation further supports its vascular protective effects.
Curdione, a naturally occurring sesquiterpenoid, exhibits significant anti-platelet aggregation activity and plays a pivotal role in modulating ferroptosis in colorectal cancer through m6A methylation processes involving METTL14 and YTHDF2. This compound is effective in alleviating myocardial infarction-induced oxidative stress via the Keap1/Trx1/GPX4 signaling pathway and mitigating Doxorubicin-induced cardiotoxicity through activation of the Nrf2/HO-1 pathway. Additionally, Curdione demonstrates protective properties against sepsis-induced lung injury, pulmonary fibrosis, and focal cerebral ischemia, while also exhibiting antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Its modulation of DNMT1-mediated ERBB4 promoter methylation further supports its vascular protective effects.
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