CX-5461

Catalog No.: A11065
DNA/RNA Synthesis inhibitor
CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage.
Grouped product items
Product Name Price Stock Qty
CX-5461 5mg
Special Price $72.00 Regular Price $90.00
In stock
CX-5461 10mg
Special Price $128.00 Regular Price $160.00
In stock
CX-5461 50mg
Special Price $360.00 Regular Price $450.00
In stock
CX-5461 100mg
Special Price $600.00 Regular Price $750.00
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's CX-5461 has been cited by 12 publications
  • Saruul Tungalag, .et al. , Int J Hematol, 2023, Feb 13 PMID: 36780110
  • Martine Chebrout, .et al. , J Cell Sci, 2022, 135 (6): jcs258798 PMID: 35048992
  • Taro Mannena, .et al. , Mol Biol Cell, 2021, 32:ar33, 1-11 PMID: 34495685
  • Shuichiro Okamoto, .et al. , Biosci Biotechnol Biochem, 2020, Aug 15;1-8 PMID: 32799625
  • Ahmed Abdullah Ahmed, .et al. , Sci Rep, 2020, 10: 12192 PMID: 32699225
  • Abed Saady, .et al. , Dyes Pigm, 2020, 174: 107986
  • Jackobel AJ, .et al. , Biochim Biophys Acta Gene Regul Mech, 2019, Aug 2:194408 PMID: 31382053
  • Hiroaki Suzuki, .et al. , Cell Death Dis, 2018, Oct; 9(10): 975 PMID: 30250194
  • Anastasia Gelgor, .et al. , Oncotarget, 2018, Mar 2; 9(17): 13822-13833 PMID: 29568397
  • Wang ZF, .et al. , Cell Chem Biol, 2018, Nov 29. pii: S2451-9456(18)30378-7 PMID: 30503283
  • Yuko Fujiwara, .et al. , EBioMedicine, 2018, Jul; 33: 33-48 PMID: 30049386
  • Maïmouna Coura Kone, .et al. , Biol Reprod, 2016, Apr;94(4):95, 1-12 PMID: 26984997
  • Biological Activity
    Discription CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage.
    Targets
    Target Value
    Product Information
    Catalog Num A11065
    Formula C27H27N7O2S
    Molecular Weight 513.6
    CAS Number 1138549-36-6
    SMILES CC1=CN=C(C=N1)CNC(=O)C2=C3N(C4=CC=CC=C4S3)C5=C(C2=O)C=CC(=N5)N6CCCN(CC6)C
    Synonyms CX5461
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO <1 mg/mL
    Water Insoluble
    Ethanol DMF: Warmed: 3 mg/mL (5.84 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.47 mL 97.35 mL 194.7 mL
    0.5 mM 3.89 mL 19.47 mL 38.94 mL
    1 mM 1.95 mL 9.74 mL 19.47 mL
    5 mM 0.39 mL 1.95 mL 3.89 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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