CX-5461

Catalog No.: A11065

DNA/RNA Synthesis inhibitor

CX-5461

CX-5461 Chemical Structure

CAS NO. 1138549-36-6

CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage.

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Package Price Qty
5 mg
$90.00
10 mg
$160.00
50 mg
$450.00
100 mg
$750.00
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  • Abed Saady, .et al. Applying styryl quinolinium fluorescent probes for imaging of ribosomal RNA in living cells, Dyes Pigm, 2020, 174: 107986
  • Jackobel AJ, .et al. DNA binding preferences of S. cerevisiae RNA polymerase I Core Factor reveal a preference for the GC-minor groove and a conserved binding mechanism, Biochim Biophys Acta Gene Regul Mech, 2019, Aug 2:194408 PMID: 31382053
  • Hiroaki Suzuki, .et al. The proline–arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesi, Cell Death Dis, 2018, Oct; 9(10): 975 PMID: 30250194
  • Anastasia Gelgor, .et al. Nucleolar stress enhances lytic reactivation of the Kaposi’s sarcoma-associated herpesvirus, Oncotarget, 2018, Mar 2; 9(17): 13822–13833 PMID: 29568397
  • Wang ZF, .et al. The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules, Cell Chem Biol, 2018, Nov 29. pii: S2451-9456(18)30378-7 PMID: 30503283
  • Yuko Fujiwara, .et al. A Nucleolar Stress–Specific p53–miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network, EBioMedicine, 2018, Jul; 33: 33–48 PMID: 30049386
  • Maïmouna Coura Kone, .et al. Three-Dimensional Distribution of UBF and Nopp140 in Relationship to Ribosomal DNA Transcription During Mouse Preimplantation Development, Biol Reprod, 2016, Apr;94(4):95, 1–12 PMID: 26984997

Biological Activity

CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage.
Targets
A375 MIA PaCa-2 Pol I-driven transcription of rRNA (HCT-116, A375, MIA PaCa-2 cells) HCT-116
58 nM(ED50)74 nM(ED50)142 nM167 nM(ED50)
In vitro DMSO 0.02 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.47 mL 97.35 mL 194.7 mL
0.5 mM 3.89 mL 19.47 mL 38.94 mL
1 mM 1.95 mL 9.74 mL 19.47 mL
5 mM 0.39 mL 1.95 mL 3.89 mL

*The above data is based on the productmolecular weight 513.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11065
Actions Inhibitor
M. Wt 513.6
Formula C27H27N7O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1138549-36-6
Synonyms CX5461
SMILES CC1=CN=C(C=N1)CNC(=O)C2=C3N(C4=CC=CC=C4S3)C5=C(C2=O)C=CC(=N5)N6CCCN(CC6)C

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