CX-5461

Catalog No.: A11065

DNA/RNA Synthesis inhibitor

CX-5461 Chemical Structure

CAS NO. 1138549-36-6

CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
50 mg
$450.00
100 mg
$750.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage.
Targets
A375 MIA PaCa-2 Pol I-driven transcription of rRNA (HCT-116, A375, MIA PaCa-2 cells) HCT-116
58 nM(ED50)74 nM(ED50)142 nM167 nM(ED50)
In vitro DMSO 0.02 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.47 mL 97.35 mL 194.7 mL
0.5 mM 3.89 mL 19.47 mL 38.94 mL
1 mM 1.95 mL 9.74 mL 19.47 mL
5 mM 0.39 mL 1.95 mL 3.89 mL

*The above data is based on the productmolecular weight 513.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11065
Actions Inhibitor
M. Wt 513.6
Formula C27H27N7O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1138549-36-6
Synonyms CX5461
SMILES CC1=CN=C(C=N1)CNC(=O)C2=C3N(C4=CC=CC=C4S3)C5=C(C2=O)C=CC(=N5)N6CCCN(CC6)C

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