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CX-6258 HCl

Pan-PIM kinase inhibitor

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Catalog No. A14275

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
CX-6258 HCl 5mg A14275-5
CX-6258 HCl 10mg A14275-10
CX-6258 HCl 25mg A14275-25
CX-6258 HCl 10mM * 1mL in DMSO A14275-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3.

CX-6258 HCl

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Chemical Information

Catalog Num A14275
Actions Inhibitor
M. Wt 498.4
Formula C26H24ClN3O3.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1353859-00-3
Synonyms CX6258
SMILES CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)/C=C/4\C5=C(C=CC(=C5)Cl)NC4=O.Cl

Biological Activity

CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3.
Pim1 Pim3 Pim2
5 nM16 nM25 nM


Solubility (25°C)* In vitro DMSO 57 mg/mL heating (114.36 mM)
Water 89 mg/mL heating (178.57 mM)
Ethanol 1 mg/mL heating (2.0 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.06 mL 100.32 mL 200.64mL
0.5 mM 4.01 mL 20.06 mL 40.13 mL
1 mM 2.01 mL 10.03 mL 20.06 mL
5 mM 0.4 mL 2.01 mL 4.01 mL

*The above data is based on the productmolecular weight 498.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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