Cyclosporin A

Catalog No.: A10260

Cyclosporin A

Cyclosporin A Chemical Structure

CAS NO. 59865-13-3

Cyclosporin A (Cyclosporine A) is an immunosuppressant agent widely used in post-allogeneic organ transplant to reduce the activity of the immune system.

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25 mg
100 mg
200 mg
10mM * 1mL in DMSO
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Warning WARNING: Attention California Residents: This product can expose you to chemicals including Cyclosporin A , which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • X Jia, .et al. Arsenic Induces Hepatic Insulin Resistance via mtROS-NLRP3 Inflammasome Pathway, J Hazard Mater, 2020, Jun 4;399:123034 PMID: 32544768
  • Y Huang, .et al. STIM1 controls calcineurin/Akt/mTOR/NFATC2?mediated osteoclastogenesis induced by RANKL/M?CSF, Experimental and Therapeutic Medicine, 2020, 20(2), 736-747
  • Miyayama Y, .et al. Comparative study on the replication of HCV1b genome between wild type and cell culture adaptive mutant in regard to sensitivities against anti-HCV drugs, Microbiol Immunol, 2019, Dec 19 PMID: 31854467

Biological Activity

Cyclosporin A (Cyclosporine A) is an immunosuppressant agent widely used in post-allogeneic organ transplant to reduce the activity of the immune system.
calcineurin (Cell-free assay)
7 nM
In vitro (25°C) DMSO Warmed: 99 mg/mL (82.32 mM)
Water Insoluble
Ethanol Warmed: 99 mg/mL (82.32 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.32 mL 41.58 mL 83.15 mL
0.5 mM 1.66 mL 8.32 mL 16.63 mL
1 mM 0.83 mL 4.16 mL 8.32 mL
5 mM 0.17 mL 0.83 mL 1.66 mL

*The above data is based on the productmolecular weight 1202.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10260
CAS No. 59865-13-3
Formula C62H111N11O12
M. Wt 1202.6
Purity >98%
Synonyms Ciclosporin A, CsA, Ciclosporin, cyclosporine, cyclosporin,
SMILES CC[[email protected]]1C(=O)N(CC(=O)N([[email protected]](C(=O)N[[email protected]](C(=O)N([[email protected]](C(=O)N[[email protected]](C(=O)N[[email protected]@H](C(=O)N([[email protected]](C(=O)N([[email protected]](C(=O)N([[email protected]](C(=O)N([[email protected]](C(=O)N1)[[email protected]@H]([[email protected]](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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