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Cypemycin

Catalog No.: A47685
Antitumor Antibiotic
Cypemycin is a linaridin antibiotic that exhibits antitumor activity by inhibiting cancer cell proliferation. It demonstrates significant cytotoxicity against P388 leukemia cells, with an IC50 of 1.3 μg/mL. Additionally, Cypemycin is effective against various human tumor cell lines, including HeLa S3, HHCC-1, HCCS-M, and Slex, with IC50 values greater than 25 μg/mL. This compound serves as a valuable tool for researching cancer therapeutics and understanding mechanisms of tumor cell resistance.
Cypemycin 154277-21-1 Antitumor Antibiotic
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCypemycin is a linaridin antibiotic that exhibits antitumor activity by inhibiting cancer cell proliferation. It demonstrates significant cytotoxicity against P388 leukemia cells, with an IC50 of 1.3 μg/mL. Additionally, Cypemycin is effective against various human tumor cell lines, including HeLa S3, HHCC-1, HCCS-M, and Slex, with IC50 values greater than 25 μg/mL. This compound serves as a valuable tool for researching cancer therapeutics and understanding mechanisms of tumor cell resistance.
Product Information
Catalog NumA47685
FormulaC99H154N24O24S
Molecular Weight2096.49
CAS Number154277-21-1
SMILESO=C(N[C@H](C(N[C@H](C(N/C=C\SC1)=O)C(C)C)=O)CC(C)C)[C@H]1NC([C@H]([C@H](C)CC)NC(/C(NC([C@H](CO)NC(CNC([C@H](CCC(N)=O)NC([C@H]([C@H](C)CC)NC([C@H](C(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCC(N)=O)NC([C@H](C)NC([C@H](C(C)C)NC(/C(NC([C@H]3N(CCC3)C(/C(NC([C@H](C)NC([C@H]4N(CCC4)C(/C(NC([C@H](C)N(C)C)=O)=C\C)=O)=O)=O)=C\C)=O)=O)=C\C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=C\C)=O)=O
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Microbiology > Antifection > Antibiotic