Cys-McMMAF is the active payload derived from AlMcMMAF, a humanized A1 antibody specifically targeting the 5T4 antigen, conjugated to the microtubule-disrupting agent MMAF through a maleimidocaproyl linker. This compound demonstrates significant antitumor efficacy in mouse models, specifically H1975 and MDA-MB-361-DYT2, making it a valuable tool for cancer research and the development of targeted therapeutics. Cys-McMMAF is ideal for studies focused on antibody-drug conjugates and their potential in oncological therapies.
Cys-McMMAF is the active payload derived from AlMcMMAF, a humanized A1 antibody specifically targeting the 5T4 antigen, conjugated to the microtubule-disrupting agent MMAF through a maleimidocaproyl linker. This compound demonstrates significant antitumor efficacy in mouse models, specifically H1975 and MDA-MB-361-DYT2, making it a valuable tool for cancer research and the development of targeted therapeutics. Cys-McMMAF is ideal for studies focused on antibody-drug conjugates and their potential in oncological therapies.
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