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CYT387 sulfate salt is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.38 mL | 81.88 mL | 163.77 mL |
| 0.5 mM | 3.28 mL | 16.38 mL | 32.75 mL |
| 1 mM | 1.64 mL | 8.19 mL | 16.38 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.28 mL |
*The above data is based on the productmolecular weight 610.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15056 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 610.62 |
| Formula | C23H26N6O10S2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1056636-06-6 |
| Synonyms | CYT-387 sulfate, CYT 387 sulfate, momelotinib sulfate |
| SMILES | C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N.OS(=O)(=O)O.OS(=O)(=O)O |
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