Cyt387 (Momelotinib)

Catalog No.: A10263

JAK inhibitor

Cyt387 (Momelotinib)

Cyt387 (Momelotinib) Chemical Structure

CAS NO. 1056634-68-4

CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively.

Availability: In stock

Package Price Qty
10 mg
$90.00
25 mg
$160.00
50 mg
$280.00
200 mg
$650.00
10mM * 1mL in DMSO
$60.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Alex Bainbridge, .et al. IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway, Nucleic Acids Research, 2020, April

Biological Activity

CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively.
Targets
JAK1 JAK2 JAK3
11 nM18 nM155 nM
In vitro (25°C) DMSO 67 mg/mL (161.65 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+40%PEG 300+ 3% Tween80 + ddH2O 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.13 mL 120.63 mL 241.25 mL
0.5 mM 4.83 mL 24.13 mL 48.25 mL
1 mM 2.41 mL 12.06 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL

*The above data is based on the productmolecular weight 414.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10263
Actions Inhibitor
CAS No. 1056634-68-4
Formula C23H22N6O2
M. Wt 414.5
Purity >98%
Synonyms CYT 11387, Cyt-387
SMILES C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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