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Cyt387 (Momelotinib)

Cyt387 (Momelotinib)

Name: Cyt387 (Momelotinib)
Brand: Adooq Bioscience
SKU: A10263
Rating: 100 (1 reviews)

Catalog No.: A10263

JAK inhibitor

Product Citations (1)

Cyt387 (Momelotinib) Chemical Structure

CAS NO. 1056634-68-4

CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively.

Availability: In stock

Package	Price	Qty
10 mg	$90.00
25 mg	$160.00
50 mg	$280.00
200 mg	$650.00
10mM * 1mL in DMSO	$60.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Cyt387 (Momelotinib)

Alex Bainbridge, .et al. IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway, Nucleic Acids Research, 2020, April

Biological Activity

CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively.

Targets

JAK1	JAK2	JAK3
11 nM	18 nM	155 nM

Solubility *

In vitro (25°C)	DMSO	67 mg/mL (161.65 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+40%PEG 300+ 3% Tween80 + ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.13 mL	120.63 mL	241.25 mL
0.5 mM	4.83 mL	24.13 mL	48.25 mL
1 mM	2.41 mL	12.06 mL	24.13 mL
5 mM	0.48 mL	2.41 mL	4.83 mL

*The above data is based on the productmolecular weight 414.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10263
Actions	Inhibitor
CAS No.	1056634-68-4
Formula	C23H22N6O2
M. Wt	414.5
Purity	>98%
Synonyms	CYT 11387, Cyt-387
SMILES	C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.