Cytarabine 5’-monophosphate is a DNA synthesis inhibitor that acts as a metabolite of the nucleoside analog Cytarabine. It is phosphorylated by deoxycytidine kinase and subsequently incorporated into DNA by DNA polymerase α, effectively reducing the rate of DNA synthesis. At a concentration of 15 mM, it shows inhibitory effects on nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae. Additionally, at doses ranging from 3.5 to 75.1 mg/kg, it contributes to improved survival rates in L1210 leukemia mouse models, making it a valuable compound for cancer research applications.
Cytarabine 5’-monophosphate is a DNA synthesis inhibitor that acts as a metabolite of the nucleoside analog Cytarabine. It is phosphorylated by deoxycytidine kinase and subsequently incorporated into DNA by DNA polymerase α, effectively reducing the rate of DNA synthesis. At a concentration of 15 mM, it shows inhibitory effects on nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae. Additionally, at doses ranging from 3.5 to 75.1 mg/kg, it contributes to improved survival rates in L1210 leukemia mouse models, making it a valuable compound for cancer research applications.
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